HbAc test comparison -
Controls and standards were run per the manufacturer's recommendation; results were always acceptable. Data were analyzed separately by type of laboratory methodology. To evaluate the performance of the BIO-RAD Micromat II, Pearson correlations were calculated using the laboratory results as the standard.
Scatter plots and regression lines were also examined. One hundred fifty-six patients were enrolled into the study 75 from one FPC, and 81 from the other FPC. Nine different medical staff performed the rapid HbA1c testing. Therefore, paired samples were available for analysis, 73 from one site and 74 from the other.
The range of values was from 2. The laboratory method yielded a mean HbA1c value that was significantly higher than that from the Micromat II for both methodologies 7.
Again, the mean HbA1c result from the laboratory was significantly greater than the mean from the Micromat II 7. The range of results from these two methods was 3. Scatterplot and regression line of HbA1c values produced from boronate affinity HPLC and Micromat II.
Scatterplot and regression line of HbA1c values produced from immuno-turbidimetric and Micromat II methods. Scatterplot and regression line of HbA1c values produced from ion-exchange HPLC and Micromat II methods.
Regarding feasibility and acceptability of introducing the same-visit Micromat II test into the busy clinical practice setting, we found that medical assistants were able to collect and analyze samples and produce same-visit results.
However, the five minute time dedication for each individual analysis was not well tolerated by staff because of numerous competing demands that made it difficult to perform all the test steps in the time intervals prescribed.
Physicians in ambulatory settings routinely send blood samples to laboratories for HbA1c testing, and then wait several days for the HbA1c test results. Thus, patient counseling and treatment adjustments based on HbA1c levels are delayed, and at times follow-up can be lost completely.
Recent advancements in technology now make it possible for physicians to incorporate point-of-care HbA1c results to evaluate and adjust treatment of their diabetic patients.
Studies of the effect of same-visit HbA1c measurement found significantly improved glycemic control through month follow-up [ 10 , 11 ]. This technology is gaining acceptance, and is now offered by a number of manufacturers.
HbA1c testing has been studied for its effect on improved glycemic control in trials primarily conducted in specialty clinics. Yet, little is published regarding the validity of the same-visit test result, and the feasibility of using a same-visit methodology in a busy primary care setting.
The manufacturer reports a correlation coefficient of 0. The mean HbA1c level obtained from Micromat II was significantly lower than that yielded from the three types of laboratory analysis, and this difference spanned the treatment threshold level currently recommended by the American Diabetes Association ADA [ 12 ].
There are likely limitations to the generalizability of the study findings. Similarly, the correlation between the laboratory and the same-visit methodologies may be improved when conducted under ideal conditions where sources of variation in the operation of the Micromat II are minimized.
Secondly, introducing a research study into a busy clinical practice setting is often met with varying degrees of resistance. Thus, evaluating the acceptance of what may have been viewed by staff as a research technique may have limitations when generalizing the acceptance of a clinical procedure.
However, our purpose was to conduct a correlation study in the real world setting of the busy FPC. We trained all clinical staff in the calibration and specimen analysis of the point-of-care instrument.
From discussions with the clinical staff and physicians, we learned that there was variability among staff members to faithfully adhere to the Micromat II timed steps as outlined in the test kit instructions. Same-visit HbA1c testing offers potential benefits for diabetes care, as patient results are available in the same-visit.
However, clinicians should be aware that the rapid HbA1c technology may produce results that are lower than the method that they have been utilizing, and that the same-visit test may suggest a different treatment strategy than a result from their usual laboratory testing source.
To overcome this barrier, we suggest that clinicians determine how the results of a same-visit HbA1c test compare with the outside laboratory reports on which they routinely base their treatment plans before incorporating the same-visit HbA1c test into their practice.
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Hemoglobin A1c point-of-care assays; a newworld with a lot of consequences!
Cardiovascular Diabetology Skinfold measurement sites 19Article tesh Cite this compariosn. Metrics Green tea and digestion. Diabetes is an increasingly important risk factor for ischemic stroke and worsens stroke prognosis. Yet a large proportion of stroke patients who are eventually diabetic are undiagnosed. Therefore, it is important to have sensitive assessment of unrecognized hyperglycaemia in stroke patients. BMC Family Practice volume Gluten-free cookiesArticle number: comparieon Cite this Green tea and digestion. Metrics details. Glycated hemoglobin HbA1c results vary by analytical HbAc test comparison. Use of same-visit HbA1c tesf methodology holds the promise of more efficient patient care, and improved diabetes Green tea and digestion. Our objective was comparisin test rest feasibility of introducing a same-visit HbA1c methodology into busy family practice centers FPC and to calculate the correlation between the same-visit HbA1c test and the laboratory method that the clinical site was currently using for HbA1c testing. Consecutive diabetic patients 18 years of age and older having blood samples drawn for routine laboratory analysis of HbA1c were asked to provide a capillary blood sample for same-visit testing with the BIO-RAD Micromat II. We compared the results of the same-visit test to three different laboratory methods one FPC used two different laboratories.
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