Nitric oxide and immune system support -
Effects of microbial proliferation and host survival in vivo. Cooper, A. Expression of nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung.
Saeftel, M. Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection. Wilhelm, P. Scanga, C. Nabeshima, S. T cell hyporesponsiveness induced by activated macrophages through nitric oxide production in mice infected with Mycobacterium tuberculosis.
Adamson, D. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp Khanolkar-Young, S. Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-β TGF-β in leprosy lesions.
Perkins, D. Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy Gabonese children with prior mild or severe malaria.
Chiwakata, C. High levels of inducible nitric oxide synthase mRNA are associated with increased monocyte counts in blood and have a beneficial role in Plasmodium falciparum malaria. Weiss, G. Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria.
Maneerat, Y. Inducible nitric oxide synthase expression is increased in the brain in fatal cerebral malaria. Histopathology 37 , — Lee, P. Role of inducible nitric oxide synthase in transplant atherosclerosis. Vos, I.
Inhibition of inducible nitric oxide synthase improves graft function and reduces tubulointerstitial injury in renal allograft rejection.
Bobe, P. Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction. The multiplex function of nitric oxide in auto immunity.
Gilkeson, G. McCartney-Francis, N. Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease. Tarrant, T. Interleukin protects from a Th1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving IFN-γ, nitric oxide and apoptosis.
Kahn, D. Adjuvant immunotherapy is dependent on inducible nitric oxide synthase. Shi, F. Control of the autoimmune response by type 2 nitric oxide synthase. Paul-Clark, M. Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration.
Cauwels, A. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Xie, K. Activation of nitric oxide gene for inhibition of cancer metastasis.
Pervin, S. Nitric oxide—induced cytostasis and cell cycle arrest of a human breast cancer cell line MDA-MB : potential role of cyclin D1. Allione, A. Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma—dependent and IFN-gamma—independent induction of apoptosis.
Angulo, I. Blood 95 , — Berendji, D. Zinc finger transcription factor as molecular target for nitric oxide—mediated immunosuppression: inhibition of IL-2 gene expression in lymphocytes. Wang, S.
A Sp1 binding site of the tumor necrosis factor α promotor functions as a nitric oxide response element. Vodovotz, Y. Regulation of transforming growth factor β1 by nitric oxide.
Cancer Res. Zhang, Z. Activation of tumor necrosis factor-α—converting enzyme—mediated ectodomain shedding by nitric oxide. Uma, S. The heme-regulated eukaryotic initiation factor 2α kinase. A potential regulatory target for control of protein synthesis by diffusible gases. Schindler, H. NO as a signaling molecule: effects on kinases.
Niedbala, W. Effects of nitric oxide on the induction and differentiation of Th1 cells. Miles, P. Constitutive nitric oxide production by rat alveolar macrophages. Roman, V. Characterization of a constitutive type III nitric oxide synthase in human U monocytic cells: stimulation by soluble CD Immunology 91 , — Blank, C.
Murine epidermal Langerhans cells do not express inducible nitric oxide synthase. Qureshi, A. Langerhans cells express inducible nitric oxide synthase and produce nitric oxide. Ross, R. Involvement of NO in contact hypersensitivity. Lu, L. Induction of nitric oxide synthase in mouse dendritic cells by IFN-γ, endotoxin, and interaction with allogeneic T cells.
Nitric oxide production is associated with dendritic cell apoptosis. Bodnar, K. Fate of Mycobacterium tuberculosis within murine dendritic cells.
LPS induction of IκB-α degradation and iNOS expression in a skin dendritic cell line is prevented by the Janus kinase 2 inhibitor, tyrphostin B Nitric Oxide 5 , 53—61 Burnett, T.
Nitric oxide synthase—2 and expression of perforin in uterine NK cells. Cifone, M. Interleukin-2 activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-γ production.
Blood 93 , — Salvucci, O. The induction of nitric oxide by interleukin and tumor necrosis factor-α in human natural killer cells: relationship with the regulation of lytic activity.
Blood 92 , — Furuke, K. Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-α. Mannick, J. Fas-induced caspase denitrosylation.
Sciorati, C. Autocrine nitric oxide modulates CDinduced apoptosis in γδ T lymphocytes. Zhao, H. B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.
Bartholdy, C. Inducible nitric oxide synthase plays a minimal role in LCMV-induced, T cell—mediated protective immunity and immunopathology. Noda, S. Role of nitric oxide synthase type 2 in acute infection with cytomegalovirus. Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase.
Brown, C. Development of Lyme arthritis in mice deficient in inducible nitric oxide synthase. Inducible nitric oxide synthase: what difference does it make? Adams, L. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.
Smith, A. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Hertz, C. IFN-γ—dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Flodstrom, M.
A critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection. Virology , — Martins, G. Fas—FasL interaction modulates nitric oxide production in Trypanosoma cruzi —infected mice.
Immunology , — Guidotti, L. Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. Banerjee, R. Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.
Jin, Y. Neural route of cerebral Listeria monocytogenes murine infection: role of immune response mechanisms in controlling bacterial neuroinvasion.
Leitch, G. Seydel, K. Innate immunity to amebic liver abscess is dependent on γ interferon and nitric oxide in a murine model of disease. Millar, A. T cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase. Huang, H. Expression of cardiac cytokines and inducible nitric oxide synthase NOS2 in Trypanosoma cruzi —infected mice.
Bauer, P. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine in the active site of the enzyme.
Akaike, T. Viral mutation accelerated by nitric oxide production during infection in vivo. Zaragoza, C. Nitric oxide synthase protection against Coxsackievirus pancreatitis. Download references. Supported by a grant from the Deutsche Forschungsgemeinschaft SFB, A5. I thank C.
Nathan, M. Röllinghoff, U. Schleicher and Y. Vodovotz for helpful comments and sharing preprints. I apologize to all authors whose original publications I could cite only indirectly by reference to review articles because of strict space limitations.
Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich-Alexander-University of Erlangen-Nuremberg, Wasserturmstrasse 3—5, Erlangen, D, Germany. You can also search for this author in PubMed Google Scholar. Correspondence to Christian Bogdan.
Reprints and permissions. Nitric oxide and the immune response. Nat Immunol 2 , — Download citation. Issue Date : 01 October Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.
Skip to main content Thank you for visiting nature. nature nature immunology review articles article. Abstract During the past two decades, nitric oxide NO has been recognized as one of the most versatile players in the immune system.
Access through your institution. Buy or subscribe. Change institution. Learn more. Figure 1: NO pathways and antimicrobial activity. References Nathan, C. CAS PubMed Google Scholar MacMicking, J. CAS Google Scholar Stuehr, D.
CAS PubMed Google Scholar Gaston, B. CAS PubMed Google Scholar Wu, G. CAS PubMed PubMed Central Google Scholar Eiserich, J. CAS PubMed Google Scholar MacPherson, J. CAS PubMed Google Scholar Marshall, H.
CAS PubMed Google Scholar Bogdan, C. CAS PubMed Google Scholar Weinberg, J. CAS PubMed PubMed Central Google Scholar Kröncke, K. PubMed PubMed Central Google Scholar Kolb, H.
CAS PubMed Google Scholar DeGroote, M. Google Scholar Brüne, B. PubMed Google Scholar Nathan, C. CAS PubMed PubMed Central Google Scholar Bogdan, C. Google Scholar Taylor-Robinson, A. CAS PubMed Google Scholar Thüring, H.
PubMed Google Scholar Bauer, H. CAS PubMed PubMed Central Google Scholar Jimenez, J. CAS PubMed PubMed Central Google Scholar Reiling, N.
CAS PubMed Google Scholar Cruz, M. CAS PubMed Google Scholar Williams, M. CAS PubMed Google Scholar Rodriguez-Pascual, F. CAS PubMed Google Scholar Carpenter, L. CAS PubMed PubMed Central Google Scholar Kleinert, H.
CAS PubMed PubMed Central Google Scholar Dlaska, M. CAS PubMed Google Scholar Pellacani, A. CAS PubMed Google Scholar Ganster, R. CAS PubMed PubMed Central Google Scholar Karaghiosoff, M. CAS PubMed Google Scholar Chakravortty, D. CAS PubMed Google Scholar Chan, E. CAS PubMed PubMed Central Google Scholar Kristof, A.
CAS PubMed Google Scholar Umansky, V. CAS PubMed Google Scholar Connelly, L. CAS PubMed Google Scholar Förstermann, U. PubMed Google Scholar Noguchi, S. CAS PubMed Google Scholar Felley-Bosco, E. CAS PubMed PubMed Central Google Scholar Musial, A.
CAS PubMed Google Scholar Tochio, H. CAS Google Scholar Ratovitski, E. CAS PubMed Google Scholar Bucci, M. CAS PubMed Google Scholar Cao, S. CAS PubMed Google Scholar Pritchard, K. CAS PubMed Google Scholar Nuszkowski, A. CAS PubMed Google Scholar Chang, C. CAS PubMed Google Scholar Closs, E.
CAS PubMed Google Scholar Nicholson, B. Throughout his career, Dr. Goedeke has been steadfast in his commitment to leverage appropriate nutritional guidance and supplementation to encourage optimal health.
This has allowed him to ascend as one of the most trusted authorities in the arena of nutritional medicine in New Zealand. His expertise in the intricate relationship between diet, nutritional supplements, and overall health forms the backbone of his treatment approach, allowing patients to benefit from a balanced and sustainable pathway to improved wellbeing.
Just added to your cart. Continue Shopping. Close search. Home Nitric Oxide Strengthening Your Immunity: How Nitric Oxide Supplements Can Help.
Strengthening Your Immunity: How Nitric Oxide Supplements Can Help by Ron Goedeke. The Immune System's Arsenal: Key Players and Their Functions Your immune system is your body's own superhero team, tirelessly defending against invaders.
Nitric Oxide Decoded: Its Production, Release, and Biological Importance Nitric oxide NO , a simple molecule, has profound effects on health. NO's Antibacterial Action: Combatting Pathogenic Invaders When it comes to fighting off bacterial threats, NO is a heavyweight champion.
Optimising White Blood Cell Movement: NO's Role in Vasodilation and Immune Surveillance Ensuring rapid and efficient movement of our immune cells is pivotal, and NO is the key player here.
Exercise-Induced Immunity Boost: The Central Role of Nitric Oxide Embracing physical activity offers more benefits than just fitness, thanks to NO.
Defending the Airways: How NO Shields the Respiratory System from Pathogens NO is crucial for maintaining the health of our respiratory system.
Diet and Nitric Oxide: Foods That Naturally Increase NO Levels What we eat can have a profound effect on our NO levels, and by extension, our overall health. Among the dietary champions boosting NO are leafy greens.
Spinach, kale, and arugula, to name a few, are packed with nitrates. When we consume these veggies, our body converts these nitrates to nitrites and eventually to nitric oxide. Incorporating these into our diet can be a natural way to bolster our NO levels and, consequently, our health.
Beetroot has gained popularity in recent years as a superfood, and for a good reason. It's a potent source of nitrates. Whether consumed as juice, salad, or in roasted form, beetroot offers a delicious path to increased NO production. The list doesn't end with veggies. Nuts, seeds, and fruits play their part too.
Walnuts, pomegranates, and berries, for instance, ensure our body has the necessary precursors for producing NO. And for those with a sweet tooth, there's more good news. Dark chocolate, rich in flavanols, not only delights the palate but also promotes NO production.
Determining the Right Dose: Scientific Insights on NO Supplement Intake Understanding the right dose is crucial when considering nitric oxide supplementation. Safety First: Recognising and Managing Side Effects of NO Supplements While the benefits of NO are numerous, it's essential to be aware of potential side effects.
Summary The Immune System's Arsenal: Key Players and Their Functions White blood cells, particularly phagocytes and lymphocytes, are the frontline defenders in the immune system, constantly vigilant against threats.
Immune organs like the thymus and bone marrow are crucial for training these cells, while the complement system acts as additional support.
Nitric Oxide Decoded: Its Production, Release, and Biological Importance Nitric oxide NO , produced from L-arginine, plays a vital role in defending against pathogens and is involved in various bodily functions like neurotransmission and cellular respiration.
NO's Antibacterial Action: Combatting Pathogenic Invaders NO targets the DNA of pathogens, preventing their reproduction, and works alongside reactive oxygen species to enhance its defensive capabilities against a range of threats, including viruses and fungi.
Optimising White Blood Cell Movement: NO's Role in Vasodilation and Immune Surveillance NO acts as a vasodilator, improving immune cell movement to infection sites and aiding in the recognition and neutralisation of threats.
Exercise-Induced Immunity Boost: The Central Role of Nitric Oxide Exercise increases NO production, enhancing blood flow and aiding in post-exercise recovery. This process also contributes to cardiovascular health.
Defending the Airways: How NO Shields the Respiratory System from Pathogens NO is crucial in respiratory health, neutralising airborne pathogens and managing inflammation to prevent chronic respiratory conditions.
Diet and Nitric Oxide: Foods That Naturally Increase NO Levels Leafy greens, beetroot, nuts, seeds, fruits, and dark chocolate are dietary sources that naturally boost NO levels, enhancing overall health. Synergistic Support: Enhancing Immunity with NO, Vitamins, and Minerals Vitamins C and E, along with minerals like Zinc and Selenium, work synergistically with NO to bolster the immune response and maintain health.
Determining the Right Dose: Scientific Insights on NO Supplement Intake Consulting a healthcare professional for personalised NO supplement dosage is essential, considering individual health factors and ensuring supplement quality. Safety First: Recognising and Managing Side Effects of NO Supplements Awareness of potential side effects like headaches and changes in blood pressure is important when using NO supplements, emphasising the need for moderation and dietary balance.
Nitric Oxide Information For more everything you need to know about nitric oxide and the role it plays in the human body, check out our comprehensive information page here.
Related Articles. The Benefits of Nitric Oxide Enhancement. Nitric Oxide and Blood Pressure. How To Boost Nitric Oxide For Better Sex Life. How To Increase Stamina With Nitric Oxide. Improve Blood Circulation with Nitric Oxide. How Nitric Oxide Is The Natural Solution for Lowering Blood Pressure.
View all. This increases blood flow, allowing immune cells to reach infection sites more efficiently and enhancing the overall immune response. Promoting apoptosis: NO can induce apoptosis, or programmed cell death, in infected or damaged cells.
This helps to remove harmful cells while minimizing damage to healthy tissues. Regulation of immune cell migration: NO plays a role in guiding immune cells to sites of infection or injury.
It influences the expression of adhesion molecules and chemokines, which direct immune cell movement. Tumor suppression: NO has been shown to have anti-tumor properties, including inhibiting cancer cell proliferation and promoting cancer cell death.
It can also enhance the activity of natural killer cells, which target and destroy cancer cells. Therapeutic potential: The importance of NO in the immune system has led to research on its potential as a therapeutic target. Drugs designed to modulate NO production or activity may have applications in treating infections, autoimmune diseases, and even cancer.
For more everything you need to know about nitric oxide and the role it plays in the human body, check out our comprehensive information page here. We've created a Nitric Oxide boosting supplement with a combination of ingredients required by our bodies to produce optimal amounts of nitric oxide.
Our supplement comes as an easy to mix, great tasting powder, offering a therapeutic dose in each scoop. Learn more about it here. Ron Goedeke MD, BSc Hons MBChB, FNZCAM. Ron Goedeke, an expert in the domain of functional medicine, dedicates his practice to uncovering the root causes of health issues by focusing on nutrition and supplement-based healing and health optimisation strategies.
An esteemed founding member of the New Zealand College of Appearance Medicine, Dr. Goedeke's professional journey has always been aligned with cutting-edge health concepts.
Having been actively involved with the American Academy of Anti-Aging Medicine since , he brings over two decades of knowledge and experience in the field of anti-aging medicine, making him an eminent figure in this evolving realm of healthcare.
Throughout his career, Dr. Goedeke has been steadfast in his commitment to leverage appropriate nutritional guidance and supplementation to encourage optimal health.
This has allowed him to ascend as one of the most trusted authorities in the arena of nutritional medicine in New Zealand. His expertise in the intricate relationship between diet, nutritional supplements, and overall health forms the backbone of his treatment approach, allowing patients to benefit from a balanced and sustainable pathway to improved wellbeing.
References: [1] Nitric oxide and redox mechanisms in the immune response [2] Nitric oxide and the immune response [3] The role of nitric oxide in inflammatory reactions.
Disclaimer : The information provided is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or qualified healthcare provider with any questions or concerns about your health.
Never disregard or delay seeking medical advice because of something you have heard or read on this website. Last updated on the 28th of April Just added to your cart. Continue Shopping. Close search.
Home Nitric Oxide Nitric Oxide and the Immune System. Nitric Oxide and the Immune System by Ron Goedeke. Importance of a properly functioning immune system A properly functioning immune system is very important for survival. When the immune system malfunctions When your immune system doesn't work properly, you have an immune system disorder.
You may have: Primary immune deficiency, meaning that you were born with a weak immune system. Severe combined immunodeficiency SCID is one such condition. Acquired immune deficiency, meaning that you got a disease that weakens the immune system temporarily e.
measles or the flu or permanently e. An overactive immune system, which may happen with an allergic reaction. An autoimmune disease. Effects of immune system disorders When the immune system is deficient, you get too many infections that most people can fight off.
The role of nitric oxide in immune system Illicit drugs, alcohol, stress, certain medications e.
Nitric oxide NO was dystem described as syatem Nitric oxide and immune system support mediator of endothelial cell relaxation, Antioxidant-rich foods for skin health important role in hypotension. NO is an intercellular messenger Plant-based food blogs has been recognized Increase Lean Body Mass one of the most versatile players in systwm immune system. Cells of the innate immune system — macrophages, neutrophils and natural killer cells — use pattern recognition receptors to recognize the molecular patterns associated with pathogens. Activated macrophages then inhibit pathogen replication by releasing a variety of effector molecules, including NO. In addition to macrophages, a large number of other immune-system cells produce and respond to NO. Thus, NO is important as a toxic defense molecule against infectious organisms.
0 thoughts on “Nitric oxide and immune system support”