Intdrventions More Content Advance articles Editor's Lifestye Supplement Archive Antioxidant supplements for blood pressure Antibacterial products Collection Archive Submit Author Guidelines Submission Site Open Access Call for Papers Lifestule Publish? Liifestyle Google Scholar. Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program. Franks Nature Medicine The types of fats in your diet can also affect the development of diabetes. Rana JS, Li TY, Manson JE, Hu FB. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Indiana University School of Medicine, Indianapolis, IN, USA.

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contributed to the conception and design of the research questions. contributed to the study screening and data extraction. and J. did the quality assessment; D. summarized and interpreted the data.

drafted the paper; D. and V. revised it substantively. All authors edited the manuscript and approved the final version.

Correspondence to Ruth J. The authors declare the following competing interests: R. and P. are employees of the Novo Nordisk Foundation, a private philanthropic enterprise foundation.

The opinions expressed in this article do not necessarily reflect the perspectives of the Novo Nordisk Foundation. None of the other authors have any conflicts of interest to declare. Communications Medicine thanks Lisa Moran and the other, anonymous, reviewer s for their contribution to the peer review of this work.

A peer review file is available. Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Bodhini, D. Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review.

Commun Med 3 , Download citation. Received : 07 May Accepted : 18 September Published : 05 October Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

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Download PDF. Subjects Clinical trials Diabetes Disease prevention. Abstract Background The variability in the effectiveness of type 2 diabetes T2D preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention.

Methods We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. Results The 81 publications that met our criteria for inclusion are from 33 unique trials.

Conclusions We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Plain language summary Clinical trials to prevent development of type 2 diabetes T2D that test dietary and lifestyle interventions have resulted in different results for different study participants.

Introduction Diabetes affects over million people worldwide 1. Methods The systematic review protocol was pre-registered on the International Prospective Register of Systematic Reviews PROSPERO; CRD Study selection We included studies reporting the effect of a lifestyle, dietary pattern, or dietary supplement interventions vs.

Screening, data extraction, and quality assessment We used the Covidence online systematic review platform 14 for literature screening, data extraction, and consensus. Synthesis of results We collated the literature according to intervention type as lifestyle intervention programs single or multi-component , dietary pattern interventions involving modifications in diet only , or supplement intervention and effect modifier analyzed e.

Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article. Results The results of our systematic literature search are presented in the Fig. Full size image. Table 1 Description of study population and study design of the included trials grouped according to the type of intervention.

Full size table. Table 2 Efficacy of T2D preventive interventions according to sociodemographic effect modifiers. Table 3 Efficacy of T2D preventive interventions according to clinical effect modifiers.

Table 4 Efficacy of T2D preventive interventions according to behavioral effect modifiers. Table 5 Efficacy of T2D preventive interventions according to molecular effect modifiers. Discussion We performed a comprehensive systematic review to identify individual-level sociodemographic, clinical, behavioral, or molecular factors that could modify the efficacy of T2D prevention strategies.

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Author information Author notes These authors contributed equally: Deirdre K. Tobias, Jordi Merino. These authors jointly supervised this work: Viswanathan Mohan, Ruth J. Morton Population Health Research Institute, Hamilton, ON, Canada Robert W.

Tobias Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Mariam Nakabuye, Christoffer Clemmensen, Marta Guasch-Ferre, Anne Cathrine B. Fitzpatrick Department of Nutrition, Harvard T.

Chan School of Public Health, Boston, MA, USA Marta Guasch-Ferre, Paul W. Tobias Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA James S.

Pankow Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark Mathias Ried-Larsen Institute for Sports and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark Mathias Ried-Larsen Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmo, Sweden Paul W.

Franks Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Paul W. Franks Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA Sara J. Franks Department of Obstetrics and Gynaecology, The Rosie Hospital, Cambridge, UK Catherine Aiken NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK Catherine Aiken Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Jamie L.

Louis, MO, USA Amy L. Clark Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, Devon, UK Kevin Colclough, Alice Hughes, Kashyap Amratlal Patel, Katherine Young, Angus G.

Udler Department of Medicine, Harvard Medical School, Boston, MA, USA Sara J. Udler Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA Daisy Duan Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA Jamie L.

Sims Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Jamie L. Sims Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA Jamie L.

Sims Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA Ellen C. Pearson Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA Jennifer M. Gloyn Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA Jennifer M.

Gloyn University of Florida, Gainesville, FL, USA Laura M. Jacobsen Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Anna R. Kettunen Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland Jarno L. Ma Departments of Pediatrics and Clinical Genetics, Kuopio University Hospital, Kuopio, Finland Jonna M.

Männistö Department of Medicine, University of Eastern Finland, Kuopio, Finland Jonna M. Semple Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA Rachel G.

Naylor Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Bige Ozkan, Mary R. Hood Internal Medicine, University of Manitoba, Winnipeg, MB, Canada Jennifer M.

Yamamoto Department of Diabetology, APHP, Paris, France Chloé Amouyal Sorbonne Université, INSERM, NutriOmic Team, Paris, France Chloé Amouyal Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia Maxine P.

Dickens Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA Linda A. DiMeglio Richard L. Roudebush VAMC, Indianapolis, IN, USA Carmella Evans-Molina Biomedical Research Institute Girona, IdIBGi, Girona, Spain María Mercè Fernández-Balsells Diabetes, Endocrinology and Nutrition Unit Girona, University Hospital Dr Josep Trueta, Girona, Spain María Mercè Fernández-Balsells Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA Stephanie L.

Fitzpatrick University of California at San Francisco, Department of Pediatrics, Diabetes Center, San Francisco, CA, USA Stephen E. Gitelman Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA Mark O.

Goodarzi Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA Mark O. Goodarzi Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia Jessica A. Stanislawski Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA Randi K.

Hattersley Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK Angus G. Libman Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, USA S.

Alice Long Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA William L. Lowe Jr. Department of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa Ayesha A.

Petrie Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Camille E.

Scholtens Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taipei City, Taiwan Wayne Huey-Herng Sheu Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan Wayne Huey-Herng Sheu Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan Wayne Huey-Herng Sheu Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA, USA Cate Speake Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Andrea K.

Wentworth Walter and Eliza Hall Institute, Parkville, VIC, Australia John M. White School of Agriculture, Food and Wine, University of Adelaide, Adelaide, SA, Australia Shao J. Josefson Department of Clinical and Organizational Development, Chicago, IL, USA Andrea J. Philipson School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada Diana Sherifali Division of Endocrinology, Metabolism, Diabetes, University of Colorado, Boulder, CO, USA Robert H.

Eckel Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland John J. Nolan Department of Endocrinology, Wexford General Hospital, Wexford, Ireland John J. Nolan Division of Endocrinology, NorthShore University HealthSystem, Skokie, IL, USA Liana K. Billings Department of Medicine, Prtizker School of Medicine, University of Chicago, Chicago, IL, USA Liana K.

Billings Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA, USA Anna L. Gloyn Faculty of Health, Aarhus University, Aarhus, Denmark Maria F.

Gomez Departments of Pediatrics and Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA Siri Atma W. Greeley Sanford Research, Sioux Falls, SD, USA Kurt Griffin University of Washington School of Medicine, Seattle, WA, USA Irl B.

Hirsch Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA Marie-France Hivert Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada Marie-France Hivert Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea Soo Heon Kwak Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Lori M.

Laffel Broad Institute, Cambridge, MA, USA James B. Owen University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Cambridge, UK Susan E.

Pollin Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA Rodica Pop-Busui AdventHealth Translational Research Institute, Orlando, FL, USA Richard E.

Pratley Pennington Biomedical Research Center, Baton Rouge, LA, USA Leanne M. Redman MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK Robert K. Semple Yale School of Medicine, New Haven, CT, USA Jennifer L.

Sherr Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia Arianne Sweeting Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia Arianne Sweeting Kaiser Permanente Northwest, Kaiser Permanente Center for Health Research, Portland, OR, USA Kimberly K.

Vesco Clinial Research, Steno Diabetes Center Copenhagen, Herlev, Denmark Tina Vilsbøll Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Tina Vilsbøll Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr.

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Monaco , Denise M. Scholtens , Elizabeth Selvin , Wayne Huey-Herng Sheu , Cate Speake , Maggie A. Stanislawski , Nele Steenackers , Andrea K. Steck , Norbert Stefan , Julie Støy , Rachael Taylor , Sok Cin Tye , Gebresilasea Gendisha Ukke , Marzhan Urazbayeva , Bart Van der Schueren , Camille Vatier , John M.

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Eckel , John J. Nolan , Louis H. Find out how to manage stress, stay motivated, and solve problems that can slow your progress. Get the guide! Prevention Tips for Parents Not long ago, it was almost unheard of for young children or teens to get type 2 diabetes.

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Lifestyle interventions Detoxification Retreats Worldwide reported Antioxidant supplements for blood pressure interevntions the intevrentions of type 2 diabetes Fertility diet plan high-risk prventing after mid- and long-term follow-up. Information on determinants of interfentions outcome and adherence and interventuons mechanisms underlying diabetes progression Antioxidant supplements for blood pressure valuable for a more targeted implementation. Weight loss seems a major determinant prevennting diabetes Lifestylle Antioxidant supplements for blood pressure, whereas physical activity and dietary composition may contribute independently. Body composition and genetic variation may also affect the response to intervention. Lifestyle interventions are cost-effective and should be optimized to increase adherence and compliance, especially for individuals in the high-risk group with a low socioeconomic status, so that public health policy can introduce targeted implementation programs nationwide. The aims of this review are to summarize the mid- and long-term effects of lifestyle interventions on impaired glucose tolerance and type 2 diabetes mellitus and to provide determinants of intervention outcome and adherence, which can be used for future implementation of lifestyle interventions. Lifestyle intervention may improve the metabolic profile and reverse the progression towards diabetes Figure 1.