EGCG and anxiety -
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A new study in the Journal of Medicinal Food has investigated whether the contents of a cup of green tea could have specific calming properties after a stressful experience. The presence of natural polyphenols, such as the antioxidant EGCG present in green tea plus those seen in black tea, have been linked with a number of beneficial effects, including heart health, gut health and even weight management2.
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Post-traumatic stress disorder Ahxiety is EGCG and anxiety traumatic stress-related EGGCG disorder stimulated by anxisty. Green tea Metabolic health habits potent antioxidative properties, due, in part, to EGCGG catechin - epigallocatechingallate EGCG. EGCG is an important polyphenol with advantageous effects on anxiety and depression. Nevertheless, the mechanism about the inhibition of PTSD-like symptoms of EGCG is still unidentified. We examined whether EGCG improved learning and memory deficit stimulated in rats after single prolonged stress SPS. Rats were administrated intraperitoneally i.
EGCG and anxiety -
Our results suggest that EGCG alleviated SPS-stimulated learning and memory deficit by inhibiting the increase of neuroinflammation in the rat brain.
In addition, EGCG reversed the alternation of allopregnanolone and progesterone in the brain, and diminished simultaneously the hypothalamic-pituitary-adrenal axis dysfunction.
Thus, EGCG reversed learning and memory-related behavioral dysfunction and molecular alternation accelerated by traumatic stress and may be a useful therapeutic material for PTSD. Keywords: brain-derived neurotrophic factor; epigallocatechin gallate; hypothalamic—pituitary—adrenal axis; memory; post-traumatic stress disorder; proinflammatory.
Abstract Post-traumatic stress disorder PTSD is a traumatic stress-related psychiatric disorder stimulated by experience. Atun R Transitioning health systems for multimorbidity.
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This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. Department of Zoology, Faculty of Science, Alexandria University, Alexandria, , Egypt.
Nabila E. Abdelmeguid, Tasneem M. Hammad, Ashraf M. Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt. You can also search for this author in PubMed Google Scholar. All authors contributed to data collection and analysis, drafting or revising the article and approved the submitted version.
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Reprints and permissions. Abdelmeguid, N. et al. Effect of Epigallocatechingallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor.
Neurochem Res 47 , — Download citation. Received : 13 March Revised : 02 July Accepted : 20 July Published : 08 August Issue Date : November Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Download PDF. Abstract Epigallocatechin 3-gallate EGCG is a natural polyphenolic antioxidant in green tea leaves with well-known health-promoting properties.
Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF Article 22 February Ishige foliacea ameliorates depressive-like behaviors in stress hormone treated mice Article Open access 20 December Use our pre-submission checklist Avoid common mistakes on your manuscript.
Introduction Major depressive disorder MDD is considered to be a major contributing factor to health-related disability and a risk factor for suicide [ 1 ]. Chemicals and Reagents EGCG powder purity Stress Model Mice of the four test groups excluding the controls were housed in individual cages and exposed to the CUMS protocol for 8 weeks [ 30 ].
Table 1 The CUMS protocol-induced depression mouse model Full size table. Full size image. Results EGCG Ameliorates the Negative Effect of CUMS on Body Weight The data in Table 2 depict the body weights of mice under different treatments.
Table 2 Effect of EGCG and Anafranil on body weights in CUMS-exposed mice Full size table. Discussion To date, MDD is considered to be the second highest contributor to chronic disease burden among all chronic medical cases [ 42 ].
Conclusion Taken together, our results indicate that treatment with EGCG can decrease the immobility time in the FST i. Schematic diagram showing the antidepressant actions of EGCG in stressed mice. References Li Z, Ruan M, Chen J, Fang Y Major depressive disorder: advances in neuroscience research and translational applications.
Curr Opin Investig Drugs — CAS PubMed PubMed Central Google Scholar Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T et al Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression.
s Article PubMed PubMed Central Google Scholar Iovieno N, Dalton ED, Fava M, Mischoulon D Second-tier natural antidepressants: review and critique. Biostat Bioinforma Biomath —85 PubMed PubMed Central Google Scholar Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B et al Neuroinflammation and depression: a review.
Neuro Endocrinol Lett — CAS PubMed Google Scholar López López AL, Escobar Villanueva MC, Brianza Padilla M, Bonilla Jaime H, Alarcón Aguilar FJ Chronic unpredictable mild stress progressively disturbs glucose metabolism and appetite hormones in rats.
Author information Authors and Affiliations Department of Zoology, Faculty of Science, Alexandria University, Alexandria, , Egypt Nabila E. Hammad Authors Nabila E. Abdelmeguid View author publications. View author publications.
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Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4. About this article. Cite this article Abdelmeguid, N. Copy to clipboard. search Search by keyword or author Search. Check out CONTINUE SHOPPING. Blayne Andrews. HOW EGCG MAKES YOU HEALTHIER, AND THE BEST WAYS TO TAKE IT.
If you drink tea or have looked into its benefits, you might have stumbled across some of these benefits being attributed to something called EGCG. EGCG is a plant compound that is generally most concentrated in green tea. It is also found in white, oolong, and black tea, as well as in small amounts in certain foods.
These positive effects of EGCG can be found in simple bags of green tea. What is EGCG? EGCG also known as epigallocatechingallate is the main and most significant green tea polyphenol.
The benefits associated with tea consumption are believed to be due to this polyphenolic compound and other related green tea catechins. EGCG is also a potent antioxidant that helps suppress inflammation by neutralizing free radicals. This is important because an increasing amount of evidence has shown that chronic inflammation causes and advances many common diseases.
EGCG has been shown to have cancer-protective effects. It achieves this through its interaction with a protein called p This protein is a gene that essentially creates blueprints for the creation of proteins involved with the death of cancer cells in healthy individuals.
Cancer itself knows how to turn this gene off so it can continue to grow. This weakens our own innate defense mechanism against cancer cells and gives them a more suitable environment to thrive. EGCG has also been shown to starve cancer cells by inhibiting a growth factor that promotes the formation of new blood vessels.
By inhibiting this, you can take away the fuel that these cells need to survive. Can EGCG support brain health?
Ulcer prevention for runners gallate EGCG is a unique aand compound thought to reduce inflammation, aid weight loss, and Metabolic health measurements prevent heart and brain disease. Nutritional health benefits known as Metabolic health measurements gallate, EGCG is a type Anxoety plant-based compound called catechin. Catechins may ans further categorized anxieyy a larger group of plant compounds known as polyphenols 1. EGCG and other related catechins act as potent antioxidants that may protect against cellular damage caused by free radicals 1. Free radicals are highly reactive particles formed in your body that can damage your cells when their numbers get too high. Eating foods high in antioxidants like catechins may help limit free radical damage. Additionally, research suggests that catechins like EGCG may reduce inflammation and prevent certain chronic conditions, including heart disease, diabetes, and some cancers 12.
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