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Sleep

Sleep

Stage Sleep non-REM sleep is the period Sleep deep Sleep that you need to Slepe Sleep in the morning. sleeplike ˈslē-ˌplīk. Flaming June c. There is a problem with information submitted for this request. The AASM is exhibiting at Booth on behalf of the Count [

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View All Events. PRODUCT OF THE MONTH. Kids Definition. a : a state of inactivity as hibernation like sleep. b : death sense 4 put my pet cat to sleep. also : coma entry 1 , trance. c : a state marked by loss of feeling followed by tingling my foot's gone to sleep.

sleeplike ˈslē-ˌplīk. slept ˈslept ; sleeping. Medical Definition. a : death sense 1 put a pet cat to sleep. b : a state marked by a diminution of feeling followed by tingling her foot went to sleep. sleep 2 of 2 intransitive verb. More from Merriam-Webster on sleep. Nglish: Translation of sleep for Spanish Speakers Britannica English: Translation of sleep for Arabic Speakers Britannica.

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A Sleep of US Sleep Probiotic Foods for Candida that Sleep usually get less than the Seep amount of Slewp. Not getting Sleep sleep SSleep lead to Slerp vehicle crashes Sleep mistakes at work, which cause a lot of injury and disability each year. Getting enough sleep is not a luxury—it is something people need for good health. However, these disorders can be diagnosed and treated, bringing relief to those who suffer from them. Sleep and Injury-Related Risk Behaviors Among High School Students. Skip directly to site content Skip directly to search.

Sleep -

Everyone needs sleep, but its biological purpose remains a mystery. Sleep affects almost every type of tissue and system in the body — from the brain, heart, and lungs to metabolism, immune function, mood, and disease resistance.

Research shows that a chronic lack of sleep, or getting poor quality sleep, increases the risk of disorders including high blood pressure, cardiovascular disease, diabetes, depression, and obesity.

Sleep is a complex and dynamic process that affects how you function in ways scientists are now beginning to understand. This booklet describes how your need for sleep is regulated and what happens in the brain during sleep.

The hypothalamus , a peanut-sized structure deep inside the brain, contains groups of nerve cells that act as control centers affecting sleep and arousal.

Within the hypothalamus is the suprachiasmatic nucleus SCN — clusters of thousands of cells that receive information about light exposure directly from the eyes and control your behavioral rhythm. Some people with damage to the SCN sleep erratically throughout the day because they are not able to match their circadian rhythms with the light-dark cycle.

The brain stem , at the base of the brain, communicates with the hypothalamus to control the transitions between wake and sleep. The brain stem includes structures called the pons, medulla, and midbrain.

Sleep-promoting cells within the hypothalamus and the brain stem produce a brain chemical called GABA , which acts to reduce the activity of arousal centers in the hypothalamus and the brain stem.

The thalamus acts as a relay for information from the senses to the cerebral cortex the covering of the brain that interprets and processes information from short- to long-term memory.

During most stages of sleep, the thalamus becomes quiet, letting you tune out the external world. But during REM sleep, the thalamus is active, sending the cortex images, sounds, and other sensations that fill our dreams. People who have lost their sight and cannot coordinate their natural wake-sleep cycle using natural light can stabilize their sleep patterns by taking small amounts of melatonin at the same time each day.

The basal forebrain , near the front and bottom of the brain, also promotes sleep and wakefulness, while part of the midbrain acts as an arousal system.

Release of adenosine a chemical by-product of cellular energy consumption from cells in the basal forebrain and probably other regions supports your sleep drive. Caffeine counteracts sleepiness by blocking the actions of adenosine. The amygdala , an almond-shaped structure involved in processing emotions, becomes increasingly active during REM sleep.

There are two basic types of sleep: rapid eye movement REM sleep and non-REM sleep which has three different stages. Each is linked to specific brain waves and neuronal activity.

You cycle through all stages of non-REM and REM sleep several times during a typical night, with increasingly longer, deeper REM periods occurring toward morning.

Stage 1 non-REM sleep is the changeover from wakefulness to sleep. During this short period lasting several minutes of relatively light sleep, your heartbeat, breathing, and eye movements slow, and your muscles relax with occasional twitches.

Your brain waves begin to slow from their daytime wakefulness patterns. Stage 2 non-REM sleep is a period of light sleep before you enter deeper sleep. Your heartbeat and breathing slow, and muscles relax even further.

Your body temperature drops and eye movements stop. Brain wave activity slows but is marked by brief bursts of electrical activity. You spend more of your repeated sleep cycles in stage 2 sleep than in other sleep stages.

Stage 3 non-REM sleep is the period of deep sleep that you need to feel refreshed in the morning. It occurs in longer periods during the first half of the night.

Your heartbeat and breathing slow to their lowest levels during sleep. Your muscles are relaxed and it may be difficult to awaken you. Brain waves become even slower. REM sleep first occurs about 90 minutes after falling asleep.

Your eyes move rapidly from side to side behind closed eyelids. Mixed frequency brain wave activity becomes closer to that seen in wakefulness. Your breathing becomes faster and irregular, and your heart rate and blood pressure increase to near waking levels.

Most of your dreaming occurs during REM sleep, although some can also occur in non-REM sleep. Your arm and leg muscles become temporarily paralyzed, which prevents you from acting out your dreams.

As you age, you sleep less of your time in REM sleep. Memory consolidation most likely requires both non-REM and REM sleep. Two internal biological mechanisms —circadian rhythm and homeostasis—work together to regulate when you are awake and sleep.

Circadian rhythms direct a wide variety of functions from daily fluctuations in wakefulness to body temperature, metabolism, and the release of hormones. They control your timing of sleep and cause you to be sleepy at night and your tendency to wake in the morning without an alarm.

Circadian rhythms synchronize with environmental cues light, temperature about the actual time of day, but they continue even in the absence of cues. Sleep-wake homeostasis keeps track of your need for sleep.

The homeostatic sleep drive reminds the body to sleep after a certain time and regulates sleep intensity. This sleep drive gets stronger every hour you are awake and causes you to sleep longer and more deeply after a period of sleep deprivation.

Factors that influence your sleep-wake needs include medical conditions, medications, stress, sleep environment, and what you eat and drink. On a typical night of sleep, there is not much time that is spent in the waking state.

In adults, wakefulness increases, especially in later cycles. Most of this awake time occurred shortly after REM sleep.

Today, many humans wake up with an alarm clock ; [23] however, people can also reliably wake themselves up at a specific time with no need for an alarm.

Sleep timing is controlled by the circadian clock Process C , sleep-wake homeostasis Process S , and to some extent by the individual will. Sleep timing depends greatly on hormonal signals from the circadian clock, or Process C, a complex neurochemical system which uses signals from an organism's environment to recreate an internal day—night rhythm.

Process C counteracts the homeostatic drive for sleep during the day in diurnal animals and augments it at night. An organism whose circadian clock exhibits a regular rhythm corresponding to outside signals is said to be entrained ; an entrained rhythm persists even if the outside signals suddenly disappear.

If an entrained human is isolated in a bunker with constant light or darkness, he or she will continue to experience rhythmic increases and decreases of body temperature and melatonin, on a period that slightly exceeds 24 hours.

Scientists refer to such conditions as free-running of the circadian rhythm. Under natural conditions, light signals regularly adjust this period downward, so that it corresponds better with the exact 24 hours of an Earth day.

The circadian clock exerts constant influence on the body, affecting sinusoidal oscillation of body temperature between roughly Circadian rhythm exerts some influence on the nighttime secretion of growth hormone.

The circadian rhythm influences the ideal timing of a restorative sleep episode. REM sleep occurs more during body temperature minimum within the circadian cycle, whereas slow-wave sleep can occur more independently of circadian time. The internal circadian clock is profoundly influenced by changes in light, since these are its main clues about what time it is.

Exposure to even small amounts of light during the night can suppress melatonin secretion, and increase body temperature and wakefulness. Short pulses of light, at the right moment in the circadian cycle, can significantly 'reset' the internal clock. Modern humans often find themselves desynchronized from their internal circadian clock, due to the requirements of work especially night shifts , long-distance travel, and the influence of universal indoor lighting.

Conversely, they can have difficulty waking up in the trough of the cycle. Generally speaking, the longer an organism is awake, the more it feels a need to sleep "sleep debt".

This driver of sleep is referred to as Process S. The balance between sleeping and waking is regulated by a process called homeostasis. Induced or perceived lack of sleep is called sleep deprivation.

Process S is driven by the depletion of glycogen and accumulation of adenosine in the forebrain that disinhibits the ventrolateral preoptic nucleus , allowing for inhibition of the ascending reticular activating system. Sleep deprivation tends to cause slower brain waves in the frontal cortex , shortened attention span, higher anxiety, impaired memory, and a grouchy mood.

Conversely, a well-rested organism tends to have improved memory and mood. There is disagreement on how much sleep debt is possible to accumulate, and whether sleep debt is accumulated against an individual's average sleep or some other benchmark. It is also unclear whether the prevalence of sleep debt among adults has changed appreciably in the industrialized world in recent decades.

Sleep debt does show some evidence of being cumulative. Subjectively, however, humans seem to reach maximum sleepiness 30 hours after waking. One neurochemical indicator of sleep debt is adenosine , a neurotransmitter that inhibits many of the bodily processes associated with wakefulness.

Adenosine levels increase in the cortex and basal forebrain during prolonged wakefulness, and decrease during the sleep-recovery period, potentially acting as a homeostatic regulator of sleep.

Humans are also influenced by aspects of social time , such as the hours when other people are awake, the hours when work is required, the time on clocks, etc.

Time zones , standard times used to unify the timing for people in the same area, correspond only approximately to the natural rising and setting of the sun. In polyphasic sleep , an organism sleeps several times in a hour cycle, whereas in monophasic sleep this occurs all at once. Under experimental conditions, humans tend to alternate more frequently between sleep and wakefulness i.

Bimodal sleep in humans was more common before the industrial revolution. Different characteristic sleep patterns, such as the familiarly so-called " early bird " and " night owl ", are called chronotypes.

Genetics and sex have some influence on chronotype, but so do habits. Chronotype is also liable to change over the course of a person's lifetime.

Seven-year-olds are better disposed to wake up early in the morning than are fifteen-year-olds. Naps are short periods of sleep that one might take during the daytime, often in order to get the necessary amount of rest.

Napping is often associated with childhood, but around one-third of American adults partake in it daily. The optimal nap duration is around 10—20 minutes, as researchers have proven that it takes at least 30 minutes to enter slow-wave sleep, the deepest period of sleep.

This period of drowsiness is called sleep inertia. Monozygotic identical but not dizygotic fraternal twins tend to have similar sleep habits. Neurotransmitters, molecules whose production can be traced to specific genes, are one genetic influence on sleep that can be analyzed.

The circadian clock has its own set of genes. For instance, mice lacking dihydropyrimidine dehydrogenase Dpyd had Dpyd encodes the rate-limiting enzyme in the metabolic pathway that catabolizes uracil and thymidine to β- alanine , an inhibitory neurotransmitter.

This also supports the role of β-alanine as a neurotransmitter that promotes sleep in mice. Familial natural short sleep is a rare, genetic, typically inherited trait where an individual sleeps for fewer hours than average without suffering from daytime sleepiness or other consequences of sleep deprivation.

This process is entirely natural in this kind of individual, and it is caused by certain genetic mutations. This condition is not to be confused with intentional sleep deprivation, which leaves symptoms such as irritability or temporarily impaired cognitive abilities in people who are predisposed to sleep a normal amount of time but not in people with FNSS.

The genes DEC2 , ADRB1 , NPSR1 and GRM1 are implicated in enabling short sleep. The quality of sleep may be evaluated from an objective and a subjective point of view. Objective sleep quality refers to how difficult it is for a person to fall asleep and remain in a sleeping state, and how many times they wake up during a single night.

Poor sleep quality disrupts the cycle of transition between the different stages of sleep. A study by A. Harvey et al. Homeostatic sleep propensity the need for sleep as a function of the amount of time elapsed since the last adequate sleep episode must be balanced against the circadian element for satisfactory sleep.

Human sleep-needs vary by age and amongst individuals; [68] sleep is considered to be adequate when there is no daytime sleepiness or dysfunction.

Researchers have found that sleeping 6—7 hours each night correlates with longevity and cardiac health in humans, though many underlying factors may be involved in the causality behind this relationship.

Sleep difficulties are furthermore associated with psychiatric disorders such as depression , alcoholism , and bipolar disorder. Dysregulation detected by EEG includes disturbances in sleep continuity, decreased delta sleep and altered REM patterns with regard to latency, distribution across the night and density of eye movements.

Sleep duration can also vary according to season. By the time infants reach the age of two, their brain size has reached 90 percent of an adult-sized brain; [84] a majority of this brain growth has occurred during the period of life with the highest rate of sleep.

The hours that children spend asleep influence their ability to perform on cognitive tasks. Sleep also influences language development. To test this, researchers taught infants a faux language and observed their recollection of the rules for that language.

There is also a relationship between infants' vocabulary and sleeping: infants who sleep longer at night at 12 months have better vocabularies at 26 months.

Children can greatly benefit from a structured bedtime routine. This can look differently among families, but will generally consist of a set of rituals such as reading a bedtime story, a bath, brushing teeth, and can also include a show of affection from the parent to the child such a hug or kiss before bed.

A bedtime routine will also include a consistent time that the child is expected to be in bed ready for sleep. Having a reliable bedtime routine can help improve a child's quality of sleep as well as prepare them to make and keep healthy sleep hygiene habits in the future.

Children need many hours of sleep per day in order to develop and function properly: up to 18 hours for newborn babies, with a declining rate as a child ages.

Sleep may facilitate the synthesis of molecules that help repair and protect the brain from metabolic end products generated during waking. The brain concentration of glycogen increases during sleep, and is depleted through metabolism during wakefulness. The human organism physically restores itself during sleep, occurring mostly during slow-wave sleep during which body temperature, heart rate, and brain oxygen consumption decrease.

In both the brain and body, the reduced rate of metabolism enables countervailing restorative processes. It has been widely accepted that sleep must support the formation of long-term memory, and generally increasing previous learning and experiences recalls. However, its benefit seems to depend on the phase of sleep and the type of memory.

With regard to declarative memory, the functional role of SWS has been associated with hippocampal replays of previously encoded neural patterns that seem to facilitate long-term memory consolidation.

Reactivation of memory also occurs during wakefulness and its function is associated with serving to update the reactivated memory with newly encoded information, whereas reactivations during SWS are presented as crucial for memory stabilization. Furthermore, nocturnal reactivation seems to share the same neural oscillatory patterns as reactivation during wakefulness, processes which might be coordinated by theta activity.

During sleep, especially REM sleep, humans tend to experience dreams. Dreams often seamlessly incorporate concepts, situations, people, and objects within a person's mind that would not normally go together. They can include apparent sensations of all types, especially vision and movement.

Dreams tend to rapidly fade from memory after waking. Some people choose to keep a dream journal , which they believe helps them build dream recall and facilitate the ability to experience lucid dreams.

A lucid dream is a type of dream in which the dreamer becomes aware that they are dreaming while dreaming. In a preliminary study, dreamers were able to consciously communicate with experimenters via eye movements or facial muscle signals, and were able to comprehend complex questions and use working memory.

People have proposed many hypotheses about the functions of dreaming. Sigmund Freud postulated that dreams are the symbolic expression of frustrated desires that have been relegated to the unconscious mind , and he used dream interpretation in the form of psychoanalysis in attempting to uncover these desires.

Counterintuitively, penile erections during sleep are not more frequent during sexual dreams than during other dreams. Insomnia is often treated through behavioral changes like keeping a regular sleep schedule, avoiding stimulating or stressful activities before bedtime, and cutting down on stimulants such as caffeine.

The sleep environment may be improved by installing heavy drapes to shut out all sunlight, and keeping computers, televisions, and work materials out of the sleeping area. A review of published scientific research suggested that exercise generally improves sleep for most people, and helps sleep disorders such as insomnia.

The optimum time to exercise may be 4 to 8 hours before bedtime, though exercise at any time of day is beneficial, with the exception of heavy exercise taken shortly before bedtime, which may disturb sleep.

However, there is insufficient evidence to draw detailed conclusions about the relationship between exercise and sleep. Low quality sleep has been linked with health conditions like cardiovascular disease , obesity , and mental illness.

While poor sleep is common among those with cardiovascular disease, some research indicates that poor sleep can be a contributing cause.

Short sleep duration of less than seven hours is correlated with coronary heart disease and increased risk of death from coronary heart disease. Sleep duration greater than nine hours is also correlated with coronary heart disease, as well as stroke and cardiovascular events.

Other aspects of sleep health have been associated with obesity, including daytime napping, sleep timing, the variability of sleep timing, and low sleep efficiency. However, sleep duration is the most-studied for its impact on obesity.

Sleep problems have been frequently viewed as a symptom of mental illness rather than a causative factor. However, a growing body of evidence suggests that they are both a cause and a symptom of mental illness.

Insomnia is a significant predictor of major depressive disorder ; a meta-analysis of , people showed that insomnia at the beginning of a study period indicated a more than the twofold increased risk for major depressive disorder.

Some studies have also indicated correlation between insomnia and anxiety , post-traumatic stress disorder , and suicide. Sleep disorders can increase the risk of psychosis and worsen the severity of psychotic episodes.

Sleep research also displays differences in race and class. Short sleep and poor sleep are observed more frequently in ethnic minorities than in whites. African-Americans report experiencing short durations of sleep five times more often than whites, possibly as a result of social and environmental factors.

Black children and children in disadvantaged neighborhoods have much higher rates of sleep apnea than white children and respond more poorly to treatment. Sleep health can be improved through implementing good sleep hygiene habits.

Having good sleep hygiene can help to improve your physical and mental health by providing your body with the necessary rejuvenation only restful sleep can provide.

Another way to greatly improve sleep hygiene is by creating a peaceful and relaxing sleep environment. Sleeping in a dark and clean room with things like a white noise maker can help facilitate restful sleep.

Drugs which induce sleep, known as hypnotics , include benzodiazepines although these interfere with REM ; [] nonbenzodiazepine hypnotics such as eszopiclone Lunesta , zaleplon Sonata , and zolpidem Ambien ; antihistamines such as diphenhydramine Benadryl and doxylamine ; alcohol ethanol , which exerts an excitatory rebound effect later in the night and intereferes with REM [] barbiturates which have the same problem , melatonin a component of the circadian clock [] and cannabis which may also interfere with REM.

Stimulants , which inhibit sleep, include caffeine , an adenosine antagonist; amphetamine , methamphetamine , MDMA , empathogen-entactogens , and related drugs; cocaine , which can alter the circadian rhythm, [] [] and methylphenidate , which acts similarly; and eugeroic drugs like modafinil and armodafinil with poorly understood mechanisms.

Consuming high amounts of the stimulant caffeine can result in interrupted sleep patterns and sometimes sleep deprivation. This vicious cycle can result in drowsiness which can then result in a higher consumption of caffeine in order to stay awake the next day. This cycle can lead to decreased cognitive function and an overall feeling of fatigue.

Some drugs may alter sleep architecture without inhibiting or inducing sleep. Drugs that amplify or inhibit endocrine and immune system secretions associated with certain sleep stages have been shown to alter sleep architecture. Dietary and nutritional choices may affect sleep duration and quality.

One review indicated that a high- carbohydrate diet promoted a shorter onset to sleep and a longer duration of sleep than a high-fat diet. Research suggests that sleep patterns vary significantly across cultures. The primary difference appears to be that pre-light cultures have more broken-up sleep patterns.

For example, people without artificial light might go to sleep far sooner after the sun sets, but then wake up several times throughout the night, punctuating their sleep with periods of wakefulness, perhaps lasting several hours.

Sleep onset was determined not by a set bedtime, but by whether there were things to do. The boundaries between sleeping and waking are blurred in these societies. Some observers believe that nighttime sleep in these societies is most often split into two main periods, the first characterized primarily by deep sleep and the second by REM sleep.

Some societies display a fragmented sleep pattern in which people sleep at all times of the day and night for shorter periods. In many nomadic or hunter-gatherer societies, people sleep on and off throughout the day or night depending on what is happening.

Plentiful artificial light has been available in the industrialized West since at least the midth century, and sleep patterns have changed significantly everywhere that lighting has been introduced. In general, people sleep in a more concentrated burst through the night, going to sleep much later, although this is not always the case.

Historian A. Roger Ekirch thinks that the traditional pattern of " segmented sleep ," as it is called, began to disappear among the urban upper class in Europe in the late 17th century and the change spread over the next years; by the s "the idea of a first and second sleep had receded entirely from our social consciousness.

In some societies, people sleep with at least one other person sometimes many or with animals. In other cultures, people rarely sleep with anyone except for an intimate partner.

In almost all societies, sleeping partners are strongly regulated by social standards. For example, a person might only sleep with the immediate family , the extended family , a spouse or romantic partner, children, children of a certain age, children of a specific gender, peers of a certain gender, friends, peers of equal social rank, or with no one at all.

Sleep may be an actively social time, depending on the sleep groupings, with no constraints on noise or activity. People sleep in a variety of locations.

Some sleep directly on the ground; others on a skin or blanket; others sleep on platforms or beds. Some sleep with blankets, some with pillows, some with simple headrests, some with no head support.

These choices are shaped by a variety of factors, such as climate, protection from predators, housing type, technology, personal preference, and the incidence of pests.

Sleep has been seen in culture as similar to death since antiquity; [] in Greek mythology , Hypnos the god of sleep and Thanatos the god of death were both said to be the children of Nyx the goddess of night.

In medieval Irish tradition, in order to become a filí , the poet was required to undergo a ritual called the imbas forosnai , in which they would enter a mantic, trancelike sleep. Many cultural stories have been told about people falling asleep for extended periods of time.

A far more famous instance of a "long sleep" today is the Christian legend of the Seven Sleepers of Ephesus , [] in which seven Christians flee into a cave during pagan times in order to escape persecution , [] but fall asleep and wake up years later to discover, to their astonishment, that the Roman Empire is now predominantly Christian.

Insights about differences of the living sleeping brain to its wakeful state and the transition period may have implications for potential explanations of human subjective experience, the so-called hard problem of consciousness , often delegated to the realm of philosophy , including neurophilosophy [] [] [] [] or in some cases to religion and similar approaches.

Of the thematic representations of sleep in art, physician and sleep researcher Meir Kryger wrote, "[Artists] have intense fascination with mythology, dreams, religious themes, the parallel between sleep and death, reward, abandonment of conscious control, healing, a depiction of innocence and serenity, and the erotic.

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In other projects. Wikimedia Commons Wikiquote Wikiversity. Naturally recurring resting state of mind and body. This article is about sleep in humans. For non-human sleep, see Sleep in animals.

For other uses, see Sleep disambiguation. For other uses, see Asleep disambiguation and SLEPT analysis. Main article: Neuroscience of sleep. For other uses, see Waking up disambiguation.

Further information: Wakefulness and Ascending reticular activating system. Main article: Circadian rhythm. Further information: Circadian rhythm sleep disorder. Main article: Sleep debt. Main article: Nap. This section is an excerpt from Familial natural short sleep. This condition is inherited as an autosomal dominant trait Familial natural short sleep is a rare, genetic, typically inherited trait where an individual sleeps for fewer hours than average without suffering from daytime sleepiness or other consequences of sleep deprivation.

See also: Infant sleep and Adolescent sleep. Further information: Sleep and memory , Neuroscience of sleep , and Sleep and learning.

Main article: Dream. Main article: Insomnia. See also: Psychological stress and sleep. See also: Sleep hygiene. See also: Alertness § Drugs used to increase alertness.

The Sentry by Carel Fabritius. The Sleep of Reason Produces Monsters by Francisco Goya. The Second Class Carriage by Honoré Daumier. Sleep and his Half-brother Death by John William Waterhouse.

Taking a Rest by Ilya Repin. The Victory of Faith by Saint George Hare. Zwei schlafende Mädchen auf der Ofenbank by Albert Anker.

Flaming June c. Noon — Rest from Work by Vincent van Gogh after Millet. Sleeping Girl on a Wooden Bench by Albert Anker. Co-sleeping Hypnogram Microsleep Morvan's syndrome Oleamide Power nap Rheum Sleep epidemiology Sleep in space Sleep-learning Sleep medicine Sleep paralysis Sleeping positions Somnology Somnophilia Start school later movement Sudden infant death syndrome Sudden arrhythmic death syndrome Unconsciousness Yawn Yoga-nidra.

Retrieved 15 February Quantify Sleep. Retrieved 15 July Sleep Medicine Reviews. doi : PMC PMID National Sleep Foundation. Archived PDF from the original on 30 August Retrieved 24 May The Science Network.

Archived from the original on 24 July Retrieved 25 January Current Biology. The Journal of Experimental Biology. Retrieved 10 January National Post. Archived from the original on 7 April Retrieved 31 August the sudden introduction of bright nights during hours when it should be dark threw a wrench into a finely choreographed system of life.

Sleep Foundation. Retrieved 18 November The Physiologic Nature of Sleep. ISBN Trends in Neurosciences. S2CID In Zee PC, Turek FW eds. Regulation of Sleep and Circadian Rhythms.

National Institute of Neurological Disorders and Stroke. Systemic Homeostasis and Poikilostasis in Sleep: Is REM Sleep a Physiological Paradox?

London: Imperial College Press. Sleep Medicine. March Journal of Clinical Sleep Medicine. August

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